DSIP 5MG - MAGNUS
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, it is the only neuropeptide in history whose gene is unknown, raising serious questions regarding the actual existence of this peptide in nature.
Structure and Interactions
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme. It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursor.
Evidence supports the current belief that it is regulated by glucocorticoids.
Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ). GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.
Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.
Role of that product in disease and medicine
- Many studies have shown that this product has anticarcinogenic properties. This product is also involved in the protective functions and is involved in the switch-off of the age-related genes.
- The patients with the disorder of major depressive disorder have a significant level of DSIP. In the plasma portion and cerebrospinal fluid, the level of DSIP is seen much deviated from the normal level. But little confusion is still there like weather the level is more are less than the normal person.
- Adipogenesis has a direct link with that of the GILZ expression.
- In the treatment of epilepsy, this product is seen effective and is prescribed for the potential treatment of the epilepsy disease.
- This product also has analgesic effects on its use. It is seen that when its administration route is intracerebroventricularly then it have anti captive effects.
- It is been seen that its use may involve the high heartbeat rate, as well as possible effects on sleep, have been seen.
- The patients having Cushing syndrome have a very low level of DSIP in their plasma.
- The patients with Alzheimer’s disease have a very high level of DSIP into their plasma and this increased level is not understandable.
- This product is also effective for the proper functioning of the central nervous system in the children for the complete recovery from the antiblastomic therapy.
- This product is effective for balancing the disturbed sleep. So, patients with this disorder are prescribed this drug.
