Melanotan II
History:
In the early 1960s, researchers showed that in rats, sexual arousal is caused by alpha – MSH. It works continued in many labs up through the 1980s. Very early in the process one of the scientists, who was conducting experiments on himself with an early tool compound, melanin ll injected himself with twice the dose he intended and got an eight-hour erection along with nausea and vomiting. To pursue the sexual dysfunction agent, Melanotan ll was licensed by Competitive Technologies to Palatin Technologies. Palatin ceased development of Melanotan ll in 2000 and synthesized, patented and began to develop bremelanotide, a likely metabolite of Melanotan ll that differs from Melanotan ll in that it has a hydroxyl group where Melanotan ll has an amide. Competitive Technologies, and paying 800,000 dollars. Bremelanotide was approved for use in the United States by the Food and Drug Administration in June 2019 under the brand name Vyleesi to treat hypoactive sexual desire disorder (HSDD).
Melanotan peptides are safe and efficacious with growing long term data. Melanotan 2 is a freeze-dried peptide sealed in a sterile multi-use vial. Tanning injections of synthetic potent a-MSH allow for the development of photo-protective suntans in all skin types.
Melanotan injections act on melanocytes to stimulate melanin production. Melanin is the body’s pigment responsible for a photoprotective safe tan.
Sunless tanning injections begin with the peptide sequence: His-Phe-Arg-Trp. Melanotan peptides Melanotan II binds to melanocortin receptors influencing pigmentation, inflammation, energy, appetite and sexual function. Melanotan 2 has a small protective amino acid structure that effects the melanocortin 1, 3, 4 and 5 receptors.
Melanotan II is a small efficient molecule as compared to the linear original Melanotan II design after natural melanocyte stimulating hormone peptide. Melanotan is approximately 1,000 times more potent than natural a-MSH.
Folks who never tan, always burn in the sun, can achieve a natural tan when using Melanotan II. For people with sun allergies/mutated receptors, synthetic melanotropin peptide supplements offer life changing opportunity. A natural tan developed over time is the best defense against cancer, to which the fair skin can now acheive. Melanotan was designed to reduce cancer rates and potentially become effective as a sunless tanning agent.
Mechanism of action:
Melanotan ll acts as a non – selective agonist of the melanocortin receptors MC1, MC2, MC3, MC4, and MC5.
The extent that Melanotan ll produces melanogenesis, the is thought to be caused by activation of MC1 receptor, whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to possibly also be involved)
Other effects of Melanotan ll, mostly regarded as adverse effects, include flushing, nausea, vomiting, stretching, yawning and loss of appetite ( the last via activation of MC4).
Dosage
Typical dosage range is 0.5 to 2.0mg/day, with a preferred range of 0.5 to 1.0 mg/day
Side effects
Transient side effects of nausea, stretching and yawning, and decreased appetite were reported more frequently after injections of Melanotan-II than placebo but none required treatment.
