Kamagra for Women
Womens Viagra, so called Kamagra 100 mg produced in the form of small pink tablets. This medicine contains 100 mg of sildenafil citrate and fillers that differ from Viagra designed to treat male impotence.
Kamagra is used to treat orgasm difficulty, and is intended for cold-blooded women who are not satisfied with sexual intercourse and for women who feel unsatisfied. Kamagra treats with insufficient, incomplete sexual stimulation, which hampers painless sexual intercourse. Use of the preparation affects the deeper and more powerful orgasm, as well as can cause several orgasms in a row.
The effect of the drug has to wait 30-45 minutes, and lasts from 4 to 6 hours, with a maximum effect between the first and the fourth hour.
The sildenafil citrate contained in Kamagra blocks the enzyme phosphodiesterase type 5 and in the smooth muscle cells of the cavernous body conditions the enlargement and increase of the sensitivity of the clitoris to the tactile stimulation, which increases the sexual activity and ability to achieve orgasm.
Mechanism of Action:
Sildenafil protects cyclic guanosine monophosphate (c GMP) from degradation by c GMP – specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide in the corpus cavernosum of the genital bind to guanylate cyclase receptors, which results in an increased level of c GMP, leading to smooth muscle relaxation (vasodilation ) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increases the inflow of blood into the spongy tissue, so the erection occurs.
The molecular mechanism of smooth muscle relaxation involves the enzyme c GPM-dependent protein kinase, also known as PKG. the kinase is activated by c GMP and its phosphorylates multiple targets in the smooth muscle cells, namely myosin light phosphatase, RhoA, IP3 receptor, phospholipase C, and others. This results in a decrease in the intracellular calcium and desensitizing proteins to affect the calcium, engendering smooth muscle relaxation.
Sildenafil is a potent and selective inhibitor of c GMP- specific phosphodiesterase type 5 (PDE5), which I responsible for the degradation of c GMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of c GMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more c GMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/c GMO system, the sildenafil should not cause an erection.
Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4 (major route), but also by CYP2C9 (minor route) hepatic isoenzymes.
Kamagra can sometimes cause:
- nausea and vomiting, heartburn.
- Transient visual disturbances with blue, green, and purple dominance;
- light sensitivity;
- redness of the face with a feeling of heat;
- pain and dizziness;
- problems with nasal passage or runny nose.
The drug should not be used by women:
- Pregnant;
- after a heart attack or stroke;
- ischemic heart disease;
- with low blood pressure - less than 90/50 mmHg;
- with cardiac arrhythmia, hypertension or prone heart attacks, which can lead to serious complications, myocardial infarction and death;
- Sensitized to any substance in Lovegra;
- using nitrates (nitroglycerin, monoazotate and isosorbide diazotide);
- severe liver and kidney failure;
- with degenerative changes of the retina;
- diagnosed with leukemia.
Alcohol consumption and fatty and hearty meals may weaken the effects of Lovegra.
Keep out of the reach and sight of children.
at 15 - 25 C, in a dark and dry room.
