Salbutamol Mode Of Fat-Loss Action
One of the most effective means of promoting rapid fat loss is activation (agonism) of beta-adrenergic receptors. Beta receptor activation increases lipolysis and metabolic rate, and can decrease appetite. All these work to improve fat loss.
Prior to changes in the law, the most widely used means of doing this had been with ephedrine. The most hardcore way has been with clenbuterol. Perhaps the best way, for most, is with Salbutamol.
Medically, Salbutamol is used to improve breathing of asthmatics and patients with chronic obstructive pulmonary disease. Safe initial dosing is typically 2-4 mg taken three to four times per day. (Higher dosings are needed only with time, as downregulation occurs.)
The same dosing levels can also be effective for fat loss, for maintenance of muscle during fat loss, and often for significant increase in endurance performance and/or slight increase in strength.
Another positive effect of beta receptor activation is improvement in blood lipid profile. Salbutamol can provide a significant benefit in this regard.
Pharmacology:
The tertiary butyl group in salbutamol makes it more selective for β2 receptors, which are the predominant receptors on the bronchial smooth muscles. Activation of these receptors causes adenylyl cyclase to convert ATP to cAMP beginning the signaling cascade that ends with the inhibition of myosin phosphorylation and lowering the intracellular concentration of calcium ions (myosin phosphorylation and calcium ions are necessary for muscle contraction). The increase in the cAMP also inhibits inflammatory cells in the airway, such as basophils, eosinophils, and most especially mast cells, from releasing inflammatory mediators and cytokines. Salbutamol and another β2 receptor agonist also increase the conductance of channel sensitive to calcium and potassium ions, leading to hyperpolarization and relaxation of bronchial smooth muscles. Salbutamol is either filtered out by the kidneys directly or is first metabolized into 4’ –O- Sulfate, which is excreted in the urine.
Medical uses:
Salbutamol is typically used to treat bronchospasm (due to any cause of allergic asthma or exercise-induced) as well as chronic obstructive pulmonary disease. It is also one of the most common medicines used in rescue inhalers (short – term bronchodilators to alleviate asthma attacks)
As a beta 2 agonist, salbutamol also has used in obstetric. Intravenous salbutamol can be used as a tocolytic to relax the uterine smooth muscle to delay premature labor. While preferred over agents such as atosiban and ritodrine, its role has largely been replaced by the calcium channel blocker nifedipine, which is more effective and better tolerated. Salbutamol has been used to treat acute hyperkalemia as it stimulates potassium flow into cells, thus lowering the potassium in the blood.
Dosage
Salbutamol should be taken as tablets or liquid, not via an inhaler.
If having no experience with Salbutamol, a usually-suitable starting dose is 4 mg on arising, 2 mg about 4-6 hours later only if feeling ready for it, and another 2 mg four to six hours after that, again only if feeling ready for it. If at the end of the day it seems to dose should have been a little more, the next day, dosing can be increased, until total dosing for the day reaches about 16 mg. This is assuming that ketotifen or Benadryl are being taken as well, as is highly preferable.
Optionally, Salbutamol dosing can be twice per day, with the second dose in the early afternoon. This may be preferred if having trouble with sleep.
Caffeine at about 200 mg about three times per day will considerably improve Salbutamol’s fat loss effect, and is highly recommended.
Side Effects
The principal possible adverse side effects of Salbutamol are increased or irregular heart rate, increased blood pressure, chest pain, increased difficulty in urination if having BPH, tremors, headache, anxiety, cramps, allergic reaction, or excessive muscle pumps. Salbutamol use can also cause loss of potassium and loss of taurine.
Taurine supplementation, for example 3-5 g/day, generally solves any muscle pump problem and almost certainly addresses any problem of loss. Potassium supplementation is probably unnecessary when consuming a diet with ample fruits and vegetables, but is advisable where these are lacking. A simple way to supplement potassium is to use Lite Salt in moderate amounts.
During an anabolic steroid cycle, it can be especially problematic for a drug to increase blood pressure, as anabolic steroids themselves also can have this effect. In some cases this can rule out or limit concurrent albuterol use.
