Complex PCT
Is a dietary supplement containing arimistane (Androsta-3,5-diene-7,17-dione),N-acetyl L-cysteine (NAC) and 6-Bromo-androstane-3-17-dione.
The product is a strong aromatase inhibitor and its systematic use allows the increasing of the natural level of testosterone in the body. The addition of N-acetylcysteine contributes to the maintenance of the proper body system condition, including the improvement in the functioning of the circulatory system and the liver.
Aromatase is a key enzyme, that allows the converting of androgens into estrogens, and aromatase inhibitors (AI), as the name suggests, reduce the activity of these changes.
Aromatase inhibitors are used by the athletes in order to prevent negative results of anabolic steroids, such as gynecomastia, increased water retention or excessive adipose tissue growth.
Pharmacodynamics:
1, 4, 6 – Androstatriene – 3, 17 – iodine (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. It is used to control estrogen synthesis.
ATD was present in some over - the - counter bodybuilding supplements until 2009 as well as topical ATD solutions that work transdermally. The product was developed and commercialized in the dietary supplement market place by industry journeyman, Bruce Kneller who holds a United States Patent for use of the compound and related compound and Gaspari Nutrition. ATL has many names in sports supplements including 1, 4, 6 Stillorgan – dione, 3, 17- keto – etiochol- triene and roast – 1, 4,6 – triene – 3, 17 – dione any many others. These all refer t CAS #633- 35- 2.
ATD may cause a positive test for the anabolic steroid boldenone, of which it is a possible metabolite and production contaminant and is also prohibited in amateur and professional sports which forbids aromatase inhibitors.
Mechanism of action:
Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. As breast tissue is stimulated by estrogens, decreasing their production is a way of suppressing the recurrence of the breast tumor tissue. The main source of estrogen is ovaries in premenopausal women, while in post-menopausal women most of the body’s estrogen is produced by in peripheral tissues (outside the CNS) and also a few CAN sites in various regions within the brain. Estrogen is produced and act locally in these tissues, but not any circulation estrogen, which exerts system estrogenic effects in men and women, is the result of estrogen escaping local metabolism and spreading to the circulatory system.
Arimistane
(Androsta-3,5-diene-7,17-dione)
is a metabolite of 7-keto DHEA, which does not convert in the human body to testosterone or estrogens. Its action is very similar to the action of Aromasin, “suicide” aromatase inhibitor. Applying Arimistane permanently inhibits and switches off the aromatase enzymes which is linked with a reduction in the level of aromatase estrogen in the body system up to 85%. It has also been demonstrated that its use can reduce cortisol levels and raise the amount of luteinizing hormone (LH), and thus increasing the level of testosterone in the body.
Thanks to its properties, arimistane found itself in the sphere of interest to athletes and bodybuilders using anabolic steroids to control estrogens. Its proper use allows for effective elimination of side effects such as gynecomastia, water retention or bloating as well as prevents the increase in blood pressure. Its action is completely different from the agents such as SERM (Nolvadex) which only block these symptoms.
NAC
(N-acetyl L-cysteine)
provides the body system with a sulphur amino acid, cysteine, which is essential for the synthesis of glutathione, a strong antioxidant. The compound can also be used as a perfect antioxidant because it shows neuroprotective properties. It affects the glutamate and dopamine neurotransmissions in the brain. Some researchers classify NAC as a nootropic agent because it is believed to have a positive impact on proper cognitive skills.
The main advantage of NAC use and a reason for using it in Complex PCT is the fact that it supports liver functions and its regeneration during the periods when you use hepatocytes damaging agents.
Glutathione is one of the most important antioxidant factors in the human body system. In the liver, it acts as one of the main detoxicants. It is also involved in a variety of other functions, such as transport of amino acids and production of coenzymes. It is believed that glutathione promotes the positive nitrogen balance by facilitating the synthesis of proteins. It increases cells hydration, muscle glycogen resources and the level of growth hormone. It reduces cortisol and lactic acid levels, accelerates the reduction of adipose tissue, supports immunity and relieves symptoms of fatigue.
6-Bromo
(6-Bromo-androstane-3-17-dione)
is one of the most potent anti-estrogen compounds ever released. 6-Bromo’s huge popularity isn’t surprising given its ability to significantly increase natural testosterone levels whilst also normalising estrogen levels.
By reducing the conversion of testosterone to estrogen, 6-Bromo can be used to increase natural testosterone levels, during PCT for example. Alternatively, 6-Bromo is a great natural testosterone booster in itself. 6-Bromo is also strongly recommended when using aromatising prohormones to significantly reduce the possibility of estrogen related side effects such as water retention or gynecomastia.
