Humulin R U-100, when used subcutaneously, is usually given three or more times daily before meals. The dosage and timing of Humulin R U-100 should be individualized and determined, based on the physician's advice, in accordance with the needs of the patient. Humulin R U-100 may also be used in combination with oral antihyperglycemic agents or longer-acting insulin products to suit the needs of the individual patients with diabetes. The injection of Humulin R U-100 should be followed by a meal within approximately 30 minutes of administration.

The average range of total daily insulin requirement for maintenance therapy in insulin-treated patients without severe insulin resistance lies between 0.5 and 1 unit/kg/day. However, in pre-pubertal children it usually varies from 0.7 to 1 unit/kg/day, but can be much lower during the period of partial remission. In situations of insulin resistance, e.g. during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial dosages for patients with diabetes are often lower, e.g., 0.2 to 0.4 units/kg/day.

Humulin R U-100 may be administered by subcutaneous injection in the abdominal wall, the thigh, the gluteal region or in the upper arm. Subcutaneous injection into the abdominal wall ensures a faster absorption than from other injection sites. Injection into a lifted skin fold minimizes the risk of intramuscular injection. Injection sites should be rotated within the same region. As with all insulin, the duration of action will vary according to the dose, injection site, blood flow, temperature, and level of physical activity.

Intravenous administration of Humulin R U-100 is possible under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia.

For intravenous use, Humulin R U-100 should be used at concentrations from 0.1 unit/mL to 1 unit/mL in infusion systems with the infusion fluids 0.9% sodium chloride using polyvinyl chloride infusion bags.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Never use Humulin R U-100 if it has become viscous (thickened) or cloudy; use it only if it is clear and colorless. Humulin R U-100 should not be used after the printed expiration date.

Humulin R U-100:

Short-acting insulin to cover blood sugar increases from meals eaten just within 30 minutes

This a short-acting insulin, which means it can cover insulin needs for meals eaten within 30 minutes.

There are basically 2 types of Humulin R insulin: Humulin R U-100 and more concentrated insulin, Humulin R U-500. U-100 insulins, including Humulin R, contain 100 units per ml. it is very important to make sure you have the correct one. This product is for injection under the skin. It should not be injected into the body muscles. Doses of insulin are measured mostly in units.  With Humulin R U-100, it is important to use the syringe that is marked for U-100 insulins.

Do not use this drug:

ØIf it appears cloudy, slightly colored, or thickened, or

ØIf solid particles are visible in this drug.

If you notice your insulin requirements changing, talk to your doctor, it is very important.

Be sure to read the patient history or information that comes with your Humulin R U-100 insulin.

Also, be sure to read the instruction for use for your Humulin R U-100 vial. To learn more about this product, call The Lilly Answers Center at 1-800-LillyRx(1-800-545-5979).

Needles and pens are for single-patient use only and should not be shared, even in healthcare facilities, or disease can be spread from one individual to another.

Mixing of insulin:

This drug should only be mixed as directed by the doctor.

This drug is short-acting and is often used in combination with intermediate or long-acting insulins

Do not withdraw insulin from the pen using a syringe.

Mixing of Insulins

Humulin R U-100 should only be mixed as directed by the physician.
Humulin R U-100 is short-acting and is often used in combination with intermediate- or long-acting insulins.
The order of mixing and brand or model of syringe should be specified by the physician. A U-100 insulin syringe should always be used. Failure to use the correct syringe can lead to dosage errors.
In general, when an intermediate-acting insulin (e.g., NPH insulin isophane suspension) is mixed with short-acting soluble insulin (e.g., regular), the short-acting insulin should be drawn into the syringe first.
Storage
Not in-use (unopened): Humulin R U-100 vials not in-use should be stored in a refrigerator (2° to 8°C [36° to 46°F]), but not in the freezer.

In-use (opened): The Humulin R U-100 vial currently in-use can be kept unrefrigerated as long as it is kept as cool as possible [below 30°C (86°F)] away from heat and light. In-use vials must be used within 31 days or be discarded, even if they still contain Humulin R U-100.

Admixture: Infusion bags prepared with Humulin R U-100 as indicated under DOSAGE AND ADMINISTRATION are stable when stored in a refrigerator (2° to 8°C [36° to 46°F]) for 48 hours and then may be used at room temperature for up to an additional 48 hours.

Do not use Humulin R U-100 after the expiration date stamped on the label or if it has been frozen.