Product: GONADORELIN (GNRH) - 10 MG
Manufacture: EUROLABS PEPTIDES
Quantity: 10 MG
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Gonadorelin (GNRH) – 10 mg | EUROLABS PEPTIDES
Description and Use
Gonadorelin (also known as Gonadorelin acetate). It is the synthetic form of gonadotropin releasing hormone that is naturally produced from Hypothalamus. It is referred as a deca-peptide as per its oligopeptide unit categorization. It basically promotes the release of LH and FSH from anterior pituitary gland governed by the number of signals and pulses from GNRH and androgen-estrogen response. These gonadotropins ultimately control gametogenesis. Low frequency pulses are responsible for the release of FSH. However, high frequency pulses contribute in the release of LH. It is a realistic substitute of increasing muscle mass and strength contrasted to the anabolic steroids.
It provides increased endurance and tolerance along with the good muscle gain. This hormone medication is also used as a post cycle therapy after the course of steroids to restore the baseline levels of testosterone. It causes minimal side effects because its mechanism involves the use of its own endogenous testosterone production.
It can also be used as an anabolic restorative along with proper high calorie diet and heavy workouts or weightlifting. It is known to increase up to 10 kg of muscle mass within 4 weeks of usage. It is known to have positive effects on quick muscle recovery and aids high libido and improved fertility in men.
The gene, GNRH1 for the GnRH precursor is located on chromosome 8. In mammals, the linear decapeptide end- product is synthesized form an 89- amino acid preprohormone in the preoptic anterior hypothalamus. It is the target of the various regulatory mechanism of the hypothalamic-pituitary-gonadal axis, such as being inhibited by increased estrogen levels in the body
GnRH is secreted in thhhe hypophysial portal bloodstream at the median eminence. The portal blood carries the GnRH to the pituitary gland, which contains the gonadotrope cells, where GnRH activates its own receptor, gonadotropin-releasing hormones (GnRHR), a seven-transmembrane G-protein-coupled receptor that stimulates the beta isoform of phosphoinositide phospholipase C, which goes on to the mobile calcium and protein kinase C. this result in the activation of proteins involved in the synthesis and secretion of the gonadotropins LH and FSH. GnRH is degraded by proteolysis within a few minutes. GnRH activity is very low during childhood and is activated at puberty or adolescence. During the reproductive years, pulse activity is critical for successful reproductive function as controlled by feedback loops. However, once a pregnancy is established, GnRH activity is not required. The pulsatile activity can be disrupted by hypothalamic-pituitary disease, either dysfunction (i.e, hypothalamix suppression) or organic lesions (trauma, tumor). Elevated prolactin levels decrease GnRH activity. In contrast, hyperinsulinemia increase pulse activity leading to disorderly LH and FSH activity, as seen in polycystic ovary syndrome (PCOS). GnRH formation is congenitally absent in kallmann syndrome. So that hormonal course is very important for all of these syndromes.
Gonadorelin (GNRH)- Dosage and duration of the course
Gonadorelin (GNRH) – Drug combinations
The stacking of Gonadorelin with other peptide variants such as peptides Hexarelin DAC + Ipamorelin DAC is ideal with excellent results of muscle mass gain and strength
Gonadorelin (GNRH) – Clinical applications/ Treatment
Gonadorelin Acetate is used to treat diseases like breast and ovarian carcinoma and uterine fibroids.
Delayed puberty and male infertility along with the low libido levels are treated with the supplementation of this drug in optimal doses.
Gonadorelin (GNRH)- Instructions
This synthetic hormone should not be considered by people with the following medical conditions;
Gonadorelin (GNRH) – Side effects
Overdose and prolong use of the drug can cause some side effects like skin rashes, rapid heart rate, mild nausea, stomach discomfort.